ClpP: A distinctive family of cylindrical energy‐dependent serine proteases
- 8 May 2007
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 581 (19) , 3749-3757
- https://doi.org/10.1016/j.febslet.2007.04.076
Abstract
Processes maintaining protein homeostasis in the cell are governed by the activities of molecular chaperones that mainly assist in the folding of polypeptide chains and by a large class of proteases that regulate protein levels through degradation. ClpP proteases define a distinctive family of cylindrical, energy-dependent serine proteases that are highly conserved throughout bacteria and eukaryota. They typically interact with ATP-dependent AAA+ chaperones that bind and unfold target substrates and then translocate them into ClpP for degradation. Structural and functional studies have provided a detailed view of the mechanism of function of this class of proteases.Keywords
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