Comparative Therapeutic Effects of Vitamin D3and Its Derivatives on Experimental Renal Osteodystrophy

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Abstract
The comparative effectiveness of vitamin D3 and its derivatives in curing hyperparathyroidism and osteodystrophic bone lesions was examined in a laboratory model of renal osteodystrophy associated with marked secondary hyperparathyroidism in rats. The experimental model was prepared by a single injection of homologous glycopeptide. Plasma levels of lα25-dihydroxyvitamin D3 [lα,25(OH)2D3] appeared to decrease in the rats receiving glycopeptide. Various doses of vitamin D3 derivatives [2 or 10 μg/kg D3, 2 μg/kg 25-hydroxyvitamin D3 (25OHD3), 0.1 μg/kg lα,25(OH)2 D3, and 0.1 or 0.2 μg/kg lα-hydroxyvitamin D3 (lαOHD3)] were daily administered orally to the nephritic rats for 23 days before sacrifice. 1α,25(OH)2D3 and lαOHD3 were much more potent than 25OHD3 and D3 in reducing the hyperplasia of parathyroid glands. The potency of lαOHD3 in curing the histological changes of osteodystrophy appeared to be greater than that of lα,25(OH)2D3. The same dose level of lαOHD3 was more effective than lα,25(OH)2D3 in enhancing plasma lα,25(OH)2D3 levels.