Accelerator mass spectrometry (AMS): recent experience of its use in a clinical study and the potential future of the technique
- 1 January 2001
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 31 (8-9) , 619-632
- https://doi.org/10.1080/00498250110052724
Abstract
1. The technique of accelerator mass spectrometry (AMS) is outlined. 2. The use of AMS in an initial validation study in animals is outlined. As part of the validation of the technique, samples from the animal study were analysed by both liquid scintillation counting (LSC) and, following dilution, by AMS. The results were similar. 3. The use of AMS in support of a clinical study is described. Six healthy male human volunteers were administered 2.7mg [14Keywords
This publication has 5 references indexed in Scilit:
- A validation study comparing accelerator MS and liquid scintillation counting for analysis of 14C-labelled drugs in plasma, urine and faecal extractsJournal of Pharmaceutical and Biomedical Analysis, 2000
- Accelerator Mass Spectrometry in Pharmaceutical Research and Development A New Ultrasensitive Analytical Method for Isotope MeasurementCurrent Drug Metabolism, 2000
- Rapid Production of Graphite Without Contamination for Biomedical AMSRadiocarbon, 1992
- Radiocarbon Dating Using Electrostatic Accelerators: Negative Ions Provide the KeyScience, 1977
- Carbon-14: Direct Detection at Natural ConcentrationsScience, 1977