Structure and mechanism of the oestrogen receptor
- 1 February 2003
- journal article
- Published by Portland Press Ltd. in Biochemical Society Transactions
- Vol. 31 (1) , 56-59
- https://doi.org/10.1042/bst0310056
Abstract
We have determined the structures of the oestrogen receptor ligand-binding domain in complex with a range of ligands and with fragments of co-regulator proteins. These structures provide insights into the structural mechanisms underlying the receptor's complex pharmacological properties and how the conformation of the receptor modulates its ability to recruit co-regulators that are necessary for transcriptional activation.Keywords
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