The Genetic Mapping of a Defective Lps Response Gene in C3H/HeJ Mice
Open Access
- 1 February 1978
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 120 (2) , 422-424
- https://doi.org/10.4049/jimmunol.120.2.422
Abstract
The expression of a defective LPS response gene Lps and the major urinary protein (Mup-1) are concordantly inherited in backcross (C3H/HeJ × C57BL/6J)F1 × C3H/HeJ mice, indicating genetic linkage of these loci. Mup-1 is known to be linked to the brown coat color locus on chromosome 4 in mice; thus Lps can now be assigned to chromosome 4. A value of 0.06 ± 0.02 has been estimated for the recombination frequency between Mup-1 and Lps. We have used the polysyndactyly (Ps) mutation further to localize Lps on chromosome 4. Lps is located between the Mup-1 and Ps loci.This publication has 8 references indexed in Scilit:
- The Response of Recombinant Inbred Strains of Mice to Bacterial LipopolysaccharidesThe Journal of Immunology, 1977
- Genetic Control of B Cell Activation by Bacterial Lipopolysaccharide Is Mediated by Multiple Distinct Genes or AllelesThe Journal of Immunology, 1976
- Genetic analysis of lymphocyte activation by lipopolysaccharide EndotoxinInfection and Immunity, 1976
- Cellular Mechanism of Endotoxin Unresponsiveness in C3H/HeJ MiceThe Journal of Immunology, 1976
- Linkage of one component of the major urinary protein complex of mice to the brown coat color locusGenetics Research, 1967
- Chemical, Physical, and Biological Properties of a Lipopolysaccharide from Escherichia coli K-235*Biochemistry, 1967
- DISC ELECTROPHORESIS – II METHOD AND APPLICATION TO HUMAN SERUM PROTEINS*Annals of the New York Academy of Sciences, 1964
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951