Preosteoblast production 55 hours after a 12.5‐day spaceflight on Cosmos 1887

Publisher Website
Google Scholar
Abstract
The influence of 12.5 days of spaceflight and a 55 h stressful recovery period (at 1 g) on fibroblastlike osteoblast precursor cells was assessed in the periodontal ligament (PDL) of rats that were 91 days old at launch. Nuclear morphometry was used as a marker for precursor cell differentiation in 3 μm sections cut in the midsagittal plane from the maxillary first molar. According to nuclear volume, cells were classified as pre-osteoblasts (C + D cells, ≥120 μm3) and less differentiated progenitor cells (A+A' cells, 40-79 μm3). Compared with synchronous controls (simulated flight conditions), the 55 h postflight recovery period at 1 g resulted in a 40% decrease in the A+A' cell population, a 42% increase in the C+D cells, and a 39% increase in the number of PDL fibroblastlike cells near the bone surface. These results are consistent with a postflight osteogenic response in PDL. This recovery response occurred despite physiological stress in the flight animals that resulted in a highly significant (P ≤ 0.001) increase in adrenal weight. The data suggest that after spaceflight there is a strong and rapid recovery mechanism for osteoblast differentiation that is not suppressed by physiological stress.— Garetto, L. P.; Gonsalves, M. R.; Morey, E. R.; Durnova, G.; Roberts, W. E. Preosteoblast production 55 hours after a 12.5-day spaceflight on Cosmos 1887. FASEB J. 4: 24-38; 1990.

This publication has 5 references indexed in Scilit: