Energy-dependent efflux mediated by class L (tetL) tetracycline resistance determinant from streptococci
Open Access
- 1 October 1987
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 31 (10) , 1648-1650
- https://doi.org/10.1128/aac.31.10.1648
Abstract
The class L (TetL) tetracycline resistance determinant from streptococci specified resistance and an energy-dependent decreased accumulation of tetracycline in both Streptococcus faecalis and Escherichia coli. Using E. coli, we showed that the reduced uptake resulted from active efflux. The streptococcal class M determinant, known to render the protein synthesis machinery of S. faecalis resistant to tetracycline inhibition, did not alter tetracycline transport in either host.This publication has 19 references indexed in Scilit:
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