Azinomycins A and B, new antitumor antibiotics. III. Antitumor activity.
- 1 January 1987
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 40 (1) , 60-65
- https://doi.org/10.7164/antibiotics.40.60
Abstract
Azinomycins A and B, isolated from the culture broth of Streptomyces griseofuscus S 42227, were examined for antitumor activities against P338 leukemia, P815 mastocytoma, B-16 melanoma, Ehrlich carcinoma, Lewis lung carcinoma and Meth A fibrosarcoma. Azinomycin B was markedly effective against the intraperitoneally inoculated tumors such as P388 leukemia, B-16 melanoma and Ehrlich carcinoma. The intraperitoneal administration of azinomycin B showed 57% survivors for 45 days and 193% ILS against P388 leukemia. For Ehrlich carcinoma, azinomycin B gave 161% ILS and 63% survivors for 45 days, but solid tumors such as Lewis lung carcinoma and Meth A fibrosarcoma were not susceptible to repeated injection of this substance. Azinomycin A was somewhat less effective than azinomycin B for the tumor systems tested.This publication has 2 references indexed in Scilit:
- Azinomycins A and B, new antitumor antibiotics. II Chemical structures.CHEMICAL & PHARMACEUTICAL BULLETIN, 1986
- Azinomycins A and B, new antitumor antibiotics. I Producing organism, fermentation, isolation, and characterization.The Journal of Antibiotics, 1986