Synthetische Beiträge zur Konstitution des Cytochroms.

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Abstract
The component c of cytochrome is characterized by its: (1) absorption spectrum; (2) solubility in dilute aqueous acetic acid and insolubility in ether; and (3) capability of being split into a porphyrin of the hemato type. Keilin, in attempts to convert hemin into cytochrome-like bodies by alternate oxidation and reduction (with Na2S2O4 obtained products which showed properties (1) and (2) but analyses indicated sulfonated porphyrins. Condensation of glycine ester with protoporphyrin yielded a crystalline porphyrin-di-amino-acid ester of m.p. 163[degree] C, which also possessed properties (1) and (2). Numerous other N-bases gave similar but non-crystallizable prod-ducts. Condensation with tertiary N-ring bases (pyri-dine, collidine, quinoline) yielded products which possessed property (3) in addition. It is concluded that in natural cytochrome c the protoporphyrin is attached to a base with tertiary ring N.

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