Stacking Interactions of nucleobases: NMR-Investigations I. Selfassociation of N6,N9-Dimethyladenine and N6-Dimethyl-N9-Ethyladenine
- 1 January 1975
- journal article
- Published by Springer Nature in European Biophysics Journal
- Vol. 1 (2) , 113-120
- https://doi.org/10.1007/bf00539773
Abstract
The selfassociation of N6,N9-dimethyladenine and N6-dimethyl-N9-ethyladenine has been studied by means of NMR technique. The thermodynamic quantities have been calculated using an isodesmic NMR model with three NMR parameters (the monomer shift δM and two complex shifts δ 2 and δ 3). The dependence of the thermodynamic quantities on the NMR parameters is discussed. Special attention is given to the determination of δ M and its temperature dependence. Calculations with δ 3=2·δ 2 and δ M taken independently of temperature result in an average entropy δ S =−17.9±1.8 e.u. for N6,N9-dimethyladenine and δ S =−16.7±1.7 e.u. for N6-dimethyl-N9-ethyladenine and in an average enthalpy δH=−7.2±0.6 kcal· mol−1 for both substances investigated.Keywords
This publication has 10 references indexed in Scilit:
- Self-association studies of two adenine derivatives by equilibrium ultracentrifugationBiophysical Chemistry, 1974
- Studies of intermolecular interactions of nucleic acid bases in aqueous solutions by the proton magnetic resonance method: Self-association of 6,9-dimethyladenine and its pyrazole analogue and their association with methyl-substituted cytosine and uracilBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1973
- The Association between Purine Nucleosides and Benzene in Aqueous Solution, Studied by Proton Magnetic Resonance and Nuclear Overhauser EnhancementsZeitschrift für Naturforschung C, 1973
- Calorimetric investigation of the association of various purine bases in aqueous mediaThe Journal of Physical Chemistry, 1973
- Complex formation between purine and indole derivatives in aqueous solutions. Proton magnetic resonance studiesJournal of the American Chemical Society, 1973
- Thermodynamics and Kinetics of Base‐Stacking InteractionsEuropean Journal of Biochemistry, 1972
- Calibration of methanol nuclear magnetic resonance thermometer at low temperatureAnalytical Chemistry, 1970
- Theory of the measurement of weak molecular complexes. I. General considerationsJournal of the American Chemical Society, 1969
- Calibration of the methanol and glycol nuclear magnetic resonance thermometers with a static thermistor probeAnalytical Chemistry, 1968
- Medium effects on the nuclear magnetic resonance spectra of purinesBiochemistry, 1968