PHARMACOKINETICS OF THE CYTOSTATIC DRUGS USED IN THE CMF-REGIMEN

  • 1 January 1983
    • journal article
    • research article
    • Vol. 3  (4) , 269-272
Abstract
Clinical patients (41) were studied on the 1st day of the 1st course of the CMF-[cyclophosphamide, methotrexate, 5-fluorouracil]-regimen administered by a fixed dosage scheme depending solely on body surface area of the patient. Pharmacokinetic parameters were calculated for each drug: the data were analyzed in conformity with the usual pharmacokinetic models. A large pharmacokinetic variability was indicated, especially for cyclophosphamide (C). The large variability in plasma concentrations of C presumably is substantially attributable to the drug formula used.

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