SENSITIVITY OF EQUINE HERPESVIRUS-1 AND HERPESVIRUS-3 INVITRO TO A NEW NUCLEOSIDE ANALOG, 9-[[2-HYDROXY-1-(HYDROXYMETHYL) ETHOXY] METHYL] GUANINE

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  • 1 January 1983
    • journal article
    • research article
    • Vol. 44  (6) , 1032-1035
Abstract
The following members of the Herpesviridae family were tested to determine their sensitivities to the new antiviral drug, BIOLF-62: equine herpesvirus types 1 and 3, human herpesvirus types 1 and 2, swine herpesvirus, bovine herpesvirus type 4, feline herpesvirus, canine herpesvirus and herpes simiae virus. Equine herpesviruses 1 and 3, human herpesviruses 1 and 2, and herpes simiae virus were all sensitive to BIOLF-62 at concentrations of < 0.55 .mu.g/ml. Equine herpesvirus types 1 and 3 were particularly sensitive, viral ED50 concentrations of the drug being only 0.033 and 0.16 .mu.g/ml, respectively. Such high antiviral potency and low cell toxicity indicate that BIOLF-62 might be useful in the treatment of infected horses.