High plasma concentrations of desmethylclomipramine after chronic administration of clomipramine to a poor metabolizer
- 1 January 1987
- journal article
- conference paper
- Published by Springer Nature in European Journal of Clinical Pharmacology
- Vol. 32 (1) , 101-102
- https://doi.org/10.1007/bf00609967
Abstract
A patient showed excessive concentrations of desmethylclomipramine after receiving normal daily doses of clomipramine (Anafranil) and the elimination kinetics of the desmethylated metabolite was zero-order/saturable. Investigation showed that she was a poor metabolizer of debrisoquine and that, in addition, she had been treated with allopurinol, an inhibitor of hepatic drug metabolism.This publication has 6 references indexed in Scilit:
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