Use of Pattern Analysis to Predict Differential Relapse of Remitted Patients With Major Depression During 1 Year of Treatment With Fluoxetine or Placebo

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Abstract
DIVERSE timing1,2 and a plethora of consequences1-15 undoubtedly contribute to the difficulty in specifying the critical mechanisms of antidepressant effects.16 The success of investigations into these mechanisms would be improved if studies were restricted to biological processes having timing similar to that of efficacy. Identifying how antidepressants work might offer clues about the pathophysiological features of depressive illness and allow predictability of treatment outcome.