Transoral Small-Bowel Biopsy as an Aid in the Diagnosis of Malabsorption States

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Abstract
IT was in 1880 that Manson's1 report first established tropical sprue as a clinical entity. Eight years later, Gee's2 classic account of a distinct type of diarrhea, occurring in people of all ages but especially in children, appeared; in this article he stated, "I cannot tell whether atrophy of the glandular crypts of the intestine be ever or always present." From that time up to the present, other reports have appeared, but have not settled the issue of the presence or absence of atrophic changes in nontropical sprue. Also, very little advance has been made in determining the etiology or . . .

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