The role of the blood‐brain barrier in the aetiology of permanent brain dysfunction in hyperphenylalaninaemia
- 11 May 1988
- journal article
- research article
- Published by Wiley in Journal of Inherited Metabolic Disease
- Vol. 12 (1) , 41-46
- https://doi.org/10.1007/bf01805529
Abstract
Summary: Calculations on the rate of entry of the neutral amino acids into the brain via the blood‐brain barrier show that a considerable decrease in this rate, particularly for tryptophan and tyrosine, takes place in histidinaemia and tyrosinaemia, type II. These conditions are, however, not associated with mental retardation. It is therefore concluded that effects at the blood‐brain barrier alone do not provide an adequate explanation for the aetiology of permanent brain dysfunction in hyperphenylalaninaemia.This publication has 31 references indexed in Scilit:
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