Contributions of chaperone and glycosyltransferase activities of O-fucosyltransferase 1 to Notch signaling
Open Access
- 14 January 2008
- journal article
- research article
- Published by Springer Nature in BMC Biology
- Vol. 6 (1) , 1
- https://doi.org/10.1186/1741-7007-6-1
Abstract
O-fucosyltransferase1 (OFUT1) is a conserved ER protein essential for Notch signaling. OFUT1 glycosylates EGF domains, which can then be further modified by the N-acetylglucosaminyltransferase Fringe. OFUT1 also possesses a chaperone activity that promotes the folding and secretion of Notch. Here, we investigate the respective contributions of these activities to Notch signaling in Drosophila.Keywords
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