A New Polyether Ladder Compound Produced by the Dinoflagellate Karenia b revis
- 20 November 2004
- journal article
- review article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 68 (1) , 2-6
- https://doi.org/10.1021/np049797o
Abstract
A new ladder-frame polyether compound containing five fused ether rings was isolated from laboratory cultures of the marine dinoflagellate Karenia brevis. This compound, named brevenal, and its dimethyl acetal derivative both competitively displace brevetoxin from its binding site in rat brain synaptosomes. Significantly, these compounds are also nontoxic to fish and antagonize the toxic effects of brevetoxins in fish. The structure and biological activity of brevenal, as well as the dimethyl acetal derivative, are described in this paper.Keywords
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