Transforming Growth Factor β2 Increases in Subretinal Fluid in Rhegmatogenous Retinal Detachment with Subretinal Strands

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Abstract
Purpose: To compare transforming growth factor (TGF) β2 levels in subretinal fluid of rhegmatogenous retinal detachment with or without subretinal strand formation. Methods: We assessed total and mature TGF-β2 levels in subretinal fluid obtained from 24 eyes with rhegmatogenous retinal detachment using an enzyme-linked immunosorbent assay. Group I comprised 18 specimens from eyes without subretinal strands, while group II comprised 6 specimens from eyes with subretinal strands. Results: Total and mature TGF-β2 levels were higher in group II than in group I (p = 0.01 and p = 0.07, respectively). Conclusion: The concentrations of total and mature TGF-β2 were higher in cases of rhegmatogenous retinal detachment associated with subretinal strand formation compared to those without subretinal strand formation.