ABO compatibility and platelet transfusions of alloimmunized thrombocytopenic patients
Open Access
- 1 September 1979
- journal article
- Published by American Society of Hematology in Blood
- Vol. 54 (3) , 595-599
- https://doi.org/10.1182/blood.v54.3.595.595
Abstract
With data on 91 alloimmunized thrombocytopenic patients and 389 donor- recipient pairs matched or selectively mismatched for HLA antigens, it was observed that ABO incompatibility significantly reduced the effectiveness of platelet transfusions. The mean 24-hr recovery of platelets from histocompatible donors and from donors selectively mismatched for cross-reactive HLA antigens was decreased by approximately 23% if the donor typed for blood group A and/or B not found in the recipient. Thus, the reduction in platelet recovery associated with ABO incompatibility is not of a magnitude that would contraindicate transfusion of ABO-mismatched platelets.Keywords
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