Biological Effect of Geometrical Isomers of Retinoic Acid on Human Promyelocytic Leukemia (HL-60) Cells.
Open Access
- 1 January 1994
- journal article
- Published by Japan Academy in Proceedings of the Japan Academy, Series B
- Vol. 70 (6) , 81-86
- https://doi.org/10.2183/pjab.70.81
Abstract
Biological activities of geometrical isomers of retinoic acid on human acute promyelocytic leukemia cell line HL-60 were analized by strictly excluding the effects of artificial isomerization. Varying from previous reports, 9-cis-retinoic acid showed over tenfold higher activity than all-trans-retinoic acid. Activity of 13-cis-retinoic acid corresponded roughly to that of all-trans-retinoic acid, and activity of 9, 13-di-cis-retinoic acid was approximately 1/10 of the level of all-trans-retinoic acid. Activities of the isomers on HL-60 cells to inhibit growth and to induce differentiation into granulocytes were parallel. all-trans-Retinoic acid and 9-cis-retinoic acid acted synergetically on HL-60 cells. Further, all-trans-retinoic acid acted additively with 13-cis-retinoic acid and with 9, 13-di-cis-retinoic acid. In contrast, 9-cis-retinoic acid acted synergetically with 13-cis-retinoic acid and with 9, 13-di-cis-retinoic acid.Keywords
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