Circulation of Lymphoid Cells in Mice Infected With Friend Leukemia Virus2

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Abstract
Friend virus (FV) depressed the immune response of BALB/c mice to sheep red cells (SRC) but not to allogeneic lymphoid cells. This difference was at least partly due to the fact that the major response to SRC occurred in the spleen, for FV infection had liHie effect when SRC were given by footpad injection. In an attempt to explain the function of the spleen, the circulation of lymphoid cells was studied in normal and infected mice. As judged by 51Cr-labeling, the lymphoid organs of infected mice accepted cells more or less normally and the ability of lymphoid cells from infected mice to home to lymphoid tissue was probably unaltered, if one allows for the dilution of lymphocytes by neoplastic cells in the spleen. 75Se-labeling experiments showed that the transit of circulating lymphoid cells was greatly slowed in the infected spleen. This might affect their ability to interact with resident cells in those immune responses dependent on lymphocyte cooperation.

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