Comparison of the in vitro Activities of BB-K8 and Three Other Ammoglycosides against 215 Strains of Pseudomonas and Enterobacteriaceae with Variable Sensitivity to Kanamycin and Gentamicin
- 1 January 1975
- journal article
- research article
- Published by S. Karger AG in Chemotherapy
- Vol. 21 (1) , 45-51
- https://doi.org/10.1159/000221843
Abstract
215 gram-negative bacilli isolated from clinical materials were tested in vitro against BB-K8 by means of disc diffusion and agar dilution tests; the strains included 40 isolates resistant to gentamicin. Approximately 90% of the strains were inhibited by 3.12 μg/ml or less BB-K8. This antibiotic exhibited a comparable activity, although somewhat inferior, to that of gentamicin, against organisms sensitive to gentamicin. It was considerably more active than gentamicin, and comparable to tobramycin, against the isolates of Klebsiella-Enterobacter-Serratia spp. resistant to gentamicin, but less active than tobramycin against 11 strains of Pseudomonas resistant to gentamicin.Keywords
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