Esters of 4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]-1-piperazineethanol and related compounds as long-acting antipsychotic agents. Synthesis of the 1-adamantoate, the first crystalline base. 4
- 1 February 1977
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 20 (2) , 302-304
- https://doi.org/10.1021/jm00212a023
Abstract
A number of new esters of fluphenazine are described; among these was the 1-adamantoate, 1h, the 1st highly crystalline ester of that drug. The 1-adamantoate of pipotiazine, 2b, typically, was an oil. Following a single s.c. or i.m. injection of 25 mg/kg of either 1h or 2b, dissolved in sesame oil, each ester was a potent and long-acting inhibitor of conditioned avoidance behavior in the rat.This publication has 2 references indexed in Scilit:
- The Adamantyl Group in Medicinal Agents. II. Anabolic Steroid 17β-AdamantoatesJournal of Medicinal Chemistry, 1965
- Esters of 4-{3-[2-(Trifluoromethyl)phenothiazin-10-yl]propyl}-1-piperazineëthanol as Long-Acting Tranquilizing Agents. Synthesis of 4-{3-[2-(Trifluoromethyl)- phenothiazin-10-yl]propyl}-1-piperazineëthanol-ethyl-C14 and its Ester with Heptanoic Acid. IIIJournal of Medicinal Chemistry, 1963