Binding Interactions of Progesterone and other C21 Steroids with Rat Uterine Cytosol

1 January 1975

journal article
Published by S. Karger AG in Gynecologic and Obstetric Investigation

Vol. 6 (5) , 272-284
https://doi.org/10.1159/000301523

Abstract

The binding of progesterone and other C₂₁ steroids by rat uterine cytosol preparations was studied by equilibrium dialysis. Scatchard plots and preliminary computer-assisted analysis indicated at least two types of binding sites for progesterone. Individual Scatchard plots for cortisol and corticosterone binding were linear with K_a’s 0.4 and 1.4 × 10⁹ M^––¹, respectively. Inhibition analyses and modeling of competition experiments suggest, however, that the situation is more complex. There was no binding of labeled dexamethasone.

Keywords

PROGESTERONE BINDING
CORTICOSTEROID BINDING
RAT UTERUS
EQUILIBRIUM DIALYSIS
CYTOSOL RECEPTORS

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