Molecular Basis for Enhanced Activity of Posaconazole against Absidia corymbifera and Rhizopus oryzae
Open Access
- 1 November 2006
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 50 (11) , 3917-3919
- https://doi.org/10.1128/aac.00747-06
Abstract
Posaconazole and itraconazole were more potent inhibitors of ergosterol synthesis, in both intact cells and cell extracts from Absidia corymbifera and Rhizopus oryzae , than voriconazole and fluconazole. Similarly, expression of CYP51 from R. oryzae in Saccharomyces cerevisiae significantly increased resistance to fluconazole and voriconazole but not to posaconazole and itraconazole.Keywords
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