PROSTAGLANDINS IN BRAIN AND THE RELEASE OF PROSTAGLANDIN-LIKE COMPOUNDS FROM THE CAT CEREBELLAR CORTEX

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Abstract
A water-soluble lipid material resistant to acid and alkali treatment was found in perfusates and extracts of brain tissue, which induced contraction of the 'slow type' on the isolated rat stomach fundus. The material isolated from brain tissue extracts behaved in solvent partition systems like the prostaglandin compounds and could be purified by silicic acid and thin-layer chromatography. The smooth-muscle-stimulating activity is likely due to the trihydroxyprostaglandin compounds.