Tissue distribution and elimination of 2,8‐dihydromirex in the rat
- 1 July 1980
- journal article
- research article
- Published by Taylor & Francis in Journal of Toxicology and Environmental Health
- Vol. 6 (4) , 713-721
- https://doi.org/10.1080/15287398009529890
Abstract
The tissue distribution and elimination kinetics of 14C-labeled dihydromirex were investigated in the rat. Dihydromirex [an environmental contaminant] was distributed in all tissues examined after i.v. or oral administration; the highest concentrations were found in the fat, liver and skin. The pattern of distribution was similar to that of photomirex and mirex. Elimination of dihydromirex from the blood after an i.v. dose was expressed by a 4-compartment model, whereas fecal excretion was represented by a biphasic curve. Excretion of dihydromirex occurred predominantly in the feces; only minute amounts were found in the urine and bile. Dihydromirex constituted 90-100% of the total radioactivity in tissues and feces. No metabolite was detected.This publication has 7 references indexed in Scilit:
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