Recognition of a polymorphic monocyte antigen in HLA
- 1 August 1982
- journal article
- letter
- Published by Springer Nature in Nature
- Vol. 298 (5874) , 565-567
- https://doi.org/10.1038/298565a0
Abstract
The serological recognition of ‘new’ gene products of the HLA system can be accomplished by selecting sera with strong leucocyte antibodies and testing these against a panel of cells obtained from donors which are compatible for the known HLA antigens with the antibody producer. This approach, which we termed the HLA-CAP approach (compatible with antibody producer), was essential in the recognition of what is now called the HLA–DR locus1 and of non HLA-linked T-cell subgroups2. Using the same technique, we have defined here several sera recognizing a structure on monocytes similar to one of the alleles of the HLA-linked PL33,4 or secondary B-cell (SB)5,6 system, so far only recognized by cellular techniques.Keywords
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