Comparison of Supercritical CHF3 and CO2 and Methanol-Modified CHF3 and CO2 for Extraction of Sulfonamides from Chicken Liver
Open Access
- 1 September 1996
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of AOAC INTERNATIONAL
- Vol. 79 (5) , 1043-1049
- https://doi.org/10.1093/jaoac/79.5.1043
Abstract
Supercritical CHF3 and methanol-modified CHF3 were compared with supercritical CO2 and methanol- modified CO2 for extraction of sulfonamides from fortified chicken liver admixed with Hydromatrix. Results showed that solvating power and selectivity were higher for supercritical and methanolmodified CHF3 than for supercritical and methanolmodified C02. Visual observation showed that chicken liver extract obtained with methanol-modified CHF3 was cleaner than that obtained with methanol-modified C02. Fat precipitated in the solvent trap when CO2 was used as the extraction medium. Also, simple off-line collection of fortified chicken liver extract obtained with CO2 in a solidphase extraction cartridge (packed with either C18 or alumina) followed by phosphate buffer-methanol (50 + 50) rinse yielded an extract that required no further cleanup for analysis.Keywords
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