Natural Products Synthesis by Retro Diels-Alder Reactions IV:1Total Synthesis of (±)-Invictolide and (±)-6-Epiinvictolide
- 1 January 1993
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1993 (03) , 191-192
- https://doi.org/10.1055/s-1993-22396
Abstract
Efficient total syntheses of (±)-invictolide 8 and its 6-epimer 9 are described. Starting from enone 4, tandem conjugate addition-enolate trapping with aldehydes, followed by another 1,4-addition and retro Diels-Alder ŕeaction, afforded key intermediates 12a and 12b which were converted into precursors 15a and 15b through hydrogenation and Baeyer-Villiger oxidation.Keywords
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