HYPERGLYCEMIC AND GLYCOSURIC EFFECT OF GLUCAGON IN THE INTACT FORCE-FED RAT

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Abstract
Intact adult male rats were force-fed a high-carbohydrate diet until minimal glycosuria occurred, and were then given growth hormone (10 I.U./day), ACTH (10 I.U./day),cortisone acetate (10 mg./day) or glucagon (hyperglycemic-glycogenolytic factor, prepared from alkaline-inactivated insulin, equivalent to 10 mg. of Zn-crystalline insulin (2.5 mg. protein)/day), or glucagon in addition to one of the other hormones. Each of the hormones increased urinary and blood glucose, and combinations of glucagon with ACTH, growth hormone or cortisone produced more glycosuria and hyperglycemia than either alone. The combination with cortisone was most effective. Glucagon is diabetogenic under proper conditions.