Isolation and characterization of the first halogen containing polyether antibiotic X-14766A, a product of Streptomyces malachitofuscus subsp. downeyi.

Abstract
This report describes the isolation and chemical characterization of antibiotic X-14766A, the 1st halogen containing polyether antibiotic, from fermented cultures of S. malachitofuscus ssp. downeyi. The structure of this novel antibiotic was determined by X-ray analyses of the thallium and rubidium salts. In addition to the Cl atom, which is attached to a salicylic acid chromophore, the molecule contains a tricyclic di-spiroketal ring system and an ethyl ester group.

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