Generation of Leukotrienes from Fetal and Neonatal Porcine Blood Vessels
- 1 January 1986
- journal article
- research article
- Published by S. Karger AG in Neonatology
- Vol. 49 (2) , 109-112
- https://doi.org/10.1159/000242519
Abstract
Various blood vessels from fetal and neonatal piglets were challenged with calcium ionophore A23187, to examine the release of leukotriene-like material. All tissues released as much or more leukotriene (LT) than adult porcine tissues previously examined. The release fell with increasing gestational age. The release from the intra-abdominal umbilical vein at 11 days preterm (480 ng of LTD4-like activity per gram of tissue) was an order of magnitude higher than that previously observed. The implications with regard to control of the fetal circulatory pattern are discussed.Keywords
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