OXIME MIXTURES AND ATROPINE IN THE PROTECTION OF MICE AND RATS FROM SARIN POISONING

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Abstract
The protection provided by oral administration of mixtures of oximes prophylactically in conjunction with intramuscular atropine given therapeutically against sarin poisoning in the rat and mouse is reported. N-Methylpyridinium-2-aldoxime methane sulphonate (P-2-S) in combination with diacetylmonoxime (DAM) demonstrated a synergistic action in protecting rats from sarin which raised the protection to double the value obtained from DAM alone. A similar synergism was found for P-2-S and monoisonitrosoacetone in the rat. This combination raised the protection obtainable from either partner by a factor of 8. Both oxime mixtures were less effective in the mouse than in the rat.