DILUTION ACIDOSIS

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Abstract
In studying the effects of the rapid saline admn. upon circulation and respiration in the dog, a constant and progressive acidosis of arterial blood was noticed. Apparently this phenomenon, although previously observed, received no attention in recent literature. It was also demonstrated that this effect could be prevented by the simultaneous admn. of bicarbonate in saline which was balanced to isotonicity. The acidosis is interpreted as being the result of dilution of the total bicarbonate on the blood by pure saline. Since the CO2 production of the body tissues remains relatively constant, the H2CO3 numerator of the blood buffer H2CO3/NaHCO3 remains relatively constant and with saline admn., it is actually the NaHCO3 which is diluted, altering pH toward acidity. This concept should be kept in mind when saline admn. is carried out, particularly in the facer of existing acidosis or renal damage.

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