HIGH BIOLOGICAL-ACTIVITY OF THE SYNTHETIC COUNTERPARTS OF HYPOTHALAMIC SOMATOSTATIN-28 AND SOMATOSTATIN-25

  • 1 January 1980
    • journal article
    • research article
    • Vol. 290  (21) , 1369-1371
Abstract
Two molecules characterized as somatostatin-28 and somatostatin-4-28 (referred to as somatostatin-25) were isolated from extracts of ovine hypothalamus. They were reproduced by synthesis. In equimolar ratios and depending upon the experimental conditions, synthetic somatostatin-28 and somatostatin-25 are 3-14 times more potent than somatostatin-14 in inhibiting the basal in vitro secretion of growth hormone. Somatostatin-14 as originally isolated, apparently is a biologically-active fragment of a larger molecule of greater specific activity, rather than somatostatin-28 being a precursor of the tetradecapeptide.

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