Mobilization of theVibriopathogenicity island betweenVibrio choleraeisolates mediated by CP-T1 generalized transduction
- 1 September 2002
- journal article
- Published by Oxford University Press (OUP) in FEMS Microbiology Letters
- Vol. 214 (2) , 153-157
- https://doi.org/10.1111/j.1574-6968.2002.tb11339.x
Abstract
Pathogenicity islands are large chromosomal regions encoding virulence genes that were acquired by horizontal gene transfer and are found in a wide range of pathogenic bacteria. In toxigenic Vibrio cholerae isolates the receptor for the cholera toxin encoding filamentous phage CTXphi, the toxin-coregulated pilus, is part of the Vibrio pathogenicity island (VPI). In this paper, we show that the VPI can be transferred between O1 serogroup strains, the predominant cause of epidemic cholera, via a generalized transducing phage CP-T1.Keywords
This publication has 18 references indexed in Scilit:
- Bacteriophage–bacteriophage interactions in the evolution of pathogenic bacteriaTrends in Microbiology, 2001
- Comparison of Vibrio cholerae Pathogenicity Islands in Sixth and Seventh Pandemic StrainsInfection and Immunity, 2001
- Pathogenicity Islands and the Evolution of MicrobesAnnual Review of Microbiology, 2000
- A bacteriophage encoding a pathogenicity island, a type-IV pilus and a phage receptor in cholera bacteriaNature, 1999
- The gene for toxic shock toxin is carried by a family of mobile pathogenicity islands in Staphylococcus aureusMolecular Microbiology, 1998
- Pathogenicity islands of virulent bacteria: structure, function and impact on microbial evolutionMolecular Microbiology, 1997
- A putative integrase gene defines the distal end of a large cluster of ToxR-regulated colonization genes in Vibrio choleraeMicrobiology, 1996
- Organization of tcp, acf, and toxT genes within a ToxT‐dependent operonMolecular Microbiology, 1995
- Excision of large DNA regions termed pathogenicity islands from tRNA-specific loci in the chromosome of an Escherichia coli wild-type pathogenInfection and Immunity, 1994
- Recombinant nontoxinogenic Vibrio cholerae strains as attenuated cholera vaccine candidatesNature, 1984