Bile Acids XLI. Hepatic Microsomal 12 -Hydroxylation of Allochenodeoxycholate to Allocholate

1 May 1974

journal article
Published by Frontiers Media SA in Experimental Biology and Medicine

Vol. 146 (1) , 92-95
https://doi.org/10.3181/00379727-146-38049

Abstract

Liver microsomal preparations of male and female rabbits, chicken and human fortified with added NADPH promote 12α-hydroxylation of 3α, 7α-dihydroxy-5α-cholanic acid, allochenodeoxycholic acid, to form allocholic acid. The rabbit is superior to the chicken and human in formation of greater quantity of product. These data support the hypothesis that the coplanarity of the 5α-sterol nucleus is important for the sterochemical specificity of the 12α-hydroxylase system.

Keywords

COPLANARITY
MALE
HYDROXYLATION
MICROSOMAL
DIHYDROXY
CHOLANIC
ALLOCHENODEOXYCHOLIC
STEROCHEMICAL
ALLOCHOLIC

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