Hemodilution and anticoagulation

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Abstract
Is-chemic changes in superficial vessels of the cortex occurring after occlusion of a middle cerebral artery in animals [squirrel monkey, cat] were modified favorably by the intravenous injection of albumin and low molecular-weight dextran (Rheomacrodex). Velocity of flow in veins was increased, and pallor of cortex was reversed. Red blood in veins indicated an increased perfusion of ischemic areas. Platelet thrombi were dispersed. Dextrose was less effective than the hy-peroncotic agents, and the process of infarction was retarded longer by albumin and Rheomacrodex. None of the agents had more than a transient effect. Ischemic changes usually progressed after 30 min. 3 hr, and cerebral edema developed. Heparin did not influence ischemic changes in superficial cortical vessels.

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