High dose folic acid treatment of fragile (X) males
- 1 January 1986
- journal article
- clinical trial
- Published by Wiley in American Journal of Medical Genetics
- Vol. 23 (1-2) , 263-271
- https://doi.org/10.1002/ajmg.1320230120
Abstract
We conducted an experimental trial of high‐dose folic acid given to five males, ages 8 to 26 years, with the fra(X) syndrome. In this double blind study, each subject received 250 mg per day of folic acid for 3 months, followed by placebo for 3 months, and folic acid again for an additional three months. Based on IQ tests, behavior ratings, the Austistic Descriptors Checklist, and parental ratings, there was little evidence to suggest any positive effects seen during the administration of high‐dose folic acid. Therefore, this study has provided little support for a hypothesis of benefit of high‐dose folic acid in the treatment of the fra(X) syndrome.Keywords
This publication has 6 references indexed in Scilit:
- The autistic descriptors checklist (ADC): A preliminary reportJournal of Autism and Developmental Disorders, 1985
- Effect of folic acid treatment in the fragile X syndromeClinical Genetics, 1985
- Folate metabolism in cells from fragile X syndrome patients and carriersAmerican Journal of Medical Genetics, 1984
- Folic acid therapy in the fragile X syndromeAmerican Journal of Medical Genetics, 1984
- Treatment of Fragile-XPublished by American Academy of Pediatrics (AAP) ,1982
- IS THE FRAGILE X SYNDROME AMENABLE TO TREATMENT?The Lancet, 1982