Mapping of the genes for human endoplasmic reticular heat shock protein gp96/grp94
- 1 January 1993
- journal article
- research article
- Published by Springer Nature in Somatic Cell and Molecular Genetics
- Vol. 19 (1) , 73-81
- https://doi.org/10.1007/bf01233956
Abstract
The murine tumor rejection antigen gp96 (TRA1, mapped to mouse chromosome 10) is a member of the heat shock protein family. Using a fragment of the murine gp96 cDNA as a probe, three gp96-related human genes have been isolated and structurally characterized. They have been mapped to human chromosomes 1 (p22), 12 (q24.2 → q24.3), and 15 (q25 → q26) by Southern blot hybridization and in situ hybridization of gene-specific probes. Only one of the genes, designatedTRA1 (human chromosome 12) is a coding gene; the other genes (TRA1P1 andTRAP2) appear to be independently derived, processed pseudogenes.Keywords
This publication has 33 references indexed in Scilit:
- Characterization of the Mouse 84-kD Heat Shock Protein Gene FamilyDNA and Cell Biology, 1990
- KAR2, a karyogamy gene, is the yeast homolog of the mammalian BiP/GRP78 geneCell, 1989
- Chromosome maps of man and mouse. IVAnnals of Human Genetics, 1989
- THE HEAT-SHOCK PROTEINSAnnual Review of Genetics, 1988
- The glucose-regulated protein grp94 is related to heat shock protein hsp90Journal of Molecular Biology, 1987
- Amino acid sequence of a chicken heat shock protein derived from the complementary DNA nucleotide sequenceBiochemistry, 1986
- Nucleotide sequence of bacteriophage λ DNAJournal of Molecular Biology, 1982
- Human metallothionein genes—primary structure of the metallothionein-II gene and a related processed geneNature, 1982
- Evidence that a human β-tubulin pseudogene is derived from its corresponding mRNANature, 1982
- Assignment of the β-glucuronidase structural gene to the pter→q22 region of chromosome 7 in manCytogenetic and Genome Research, 1978