Abstract
Two criteria are postulated as essential for a radioiodine diagnostic test. The test should be indicative of thyroid status, and the test should measure a fundamental parameter of the thyroid. In support of the 2d criterion, the metabolism of labeled iodide and the release of labeled hormone by the gland are analyzed on the basis of simple models, and techniques are discussed for detn. of fundamental constants for the exptl. data. The metabolism of iodide by a myxedematous subject is presented as an example.

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