Doxycycline (Vibramycin®) in Pelvic Inflammatory Disease

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Abstract
Using standardized laparoscopy technique, fluid was aspirated from the pouch of Douglas, from the Fallopain tubes and from ovarian cysts in 85 [human] cases with clinical diagnosis of pelvic inflammatory disease (PID) [due to bacterial infection]. The concentration of doxycycline in the aspirates was measured after oral ingestion of 200 mg of doxycycline (Vibramycin). A therapeutic level was achieved in the tubes and in ovarian cysts within a few hours, and on continuation of the treatment these values followed the plasma concentration closely, still being within the therapeutic range 24 h after the final dose. The clinical effect was excellent, 94% (60/64) of the cases with verified PID being cured by doxycycline.

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