Genetic study of pancreatic proteinase in mice (Mus musculus): Genetic variants of trypsin and chymotrypsin
- 1 October 1976
- journal article
- research article
- Published by Springer Nature in Biochemical Genetics
- Vol. 14 (9-10) , 697-707
- https://doi.org/10.1007/bf00485335
Abstract
Three to five isozymes of pancreatic proteinase exist in mice, and they have been designated as bands I, II, III, IV, and V. Identification experiments of these isozymes were carried out in this study; banks I, IV, and V are trypsin, and bands II and III are chymotrypsin. Therefore, it is concluded that Prt-1, controlling band V, is a locus for trypsin and Prt-2, controlling bands II and III, is a locus for chymotrypsin. In addition, a new locus, Prt-3, has been found. At this locus the two allelic genes, Prt-3 aand Prt-3 b, control the low and high tryptic activities of band IV, respectively. Prt-3 is present only in the strain Mol-A. Linkage experimentation has shown that Prt-1 is closely linked to Prt-3.Keywords
This publication has 10 references indexed in Scilit:
- Genetic study of pancreatic proteinase and ?-amylase in mice (Mus musculus)Biochemical Genetics, 1974
- Substrate activation of rat trypsins 1 and 2Archives of Biochemistry and Biophysics, 1973
- Independent Genetic Control of the Catalytic Activity and the Rate of Degradation of Catalase in MiceJournal of Biological Chemistry, 1969
- Identification of pancreatic enzymes in human duodenal contentsBiochimica et Biophysica Acta (BBA) - Enzymology, 1968
- On chymotrypsinogen and trypsinogen biosynthesis by pancreas of rats fed on a starch-rich or a casein-rich dietBiochemical and Biophysical Research Communications, 1964
- A MODIFIED SPECTROPHOTOMETRIC DETERMINATION OF CHYMOTRYPSIN, TRYPSIN, AND THROMBINCanadian Journal of Biochemistry and Physiology, 1959
- A MODIFIED SPECTROPHOTOMETRIC DETERMINATION OF CHYMOTRYPSIN, TRYPSIN, AND THROMBINCanadian Journal of Biochemistry and Physiology, 1959
- A spectrophotometric determination of trypsin and chymotrypsinBiochimica et Biophysica Acta, 1955
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951