Acute Lymphoblastic Leukemia Occurring 18 Years after Apparent Cure of Chronic Myelogenous Leukemia

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Abstract
To the Editor: Transformation of chronic myelogenous leukemia (CML) into acute leukemia with a lymphoid phenotype is a frequent event. However, the observation of a patient in whom acute lymphoblastic leukemia (ALL) developed 18 years after what seemed to be a cure of CML is rather unusual and raises an interesting question: Are we dealing with the blastic crisis of a subclinical phase of CML or with a new leukemia? A woman whose initial story has been previously reported1 first presented in April 1960, when she was 35 years old, with marked pallor and massive splenomegaly. Blood values were as . . .

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