Ciguatoxin and brevetoxins share a common receptor site on the neuronal voltage‐dependent Na+ channel
- 27 July 1987
- journal article
- Published by Wiley in FEBS Letters
- Vol. 219 (2) , 355-359
- https://doi.org/10.1016/0014-5793(87)80252-1
Abstract
Binding studies indicate that ciguatoxin and brevetoxin allosterically enhance in a very similar way the binding of [3H]batrachotoxinin A 20-alpha-benzoate to the neuronal Na+ channel protein. Moreover ciguatoxin competitively inhibits the binding of [3H]brevetoxin-3 to rat brain membranes. The affinity of ciguatoxin for the Na+ channel is at least 20-50-times higher than that of brevetoxin. These results indicate that ciguatoxin and brevetoxins act at the same binding site on the sodium channel.Keywords
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