The use of cyclosporin in corticosteroid dependent asthma
Open Access
- 1 December 1997
- journal article
- clinical trial
- Published by BMJ in Archives of Disease in Childhood
- Vol. 77 (6) , 522-523
- https://doi.org/10.1136/adc.77.6.522
Abstract
Five children with severe asthma requiring at least 10 mg of prednisolone daily were treated with cyclosporin. Three were weaned from prednisolone, but one quickly relapsed. One girl had her steroid dose lowered but suffered unacceptable hirsutism and one child failed to respond. Cyclosporin may be useful in refractory childhood asthma. A prospective study is required to confirm this.Keywords
This publication has 6 references indexed in Scilit:
- Double-blind, placebo-controlled study of cyclosporin A as a corticosteroid-sparing agent in corticosteroid-dependent asthma.American Journal of Respiratory and Critical Care Medicine, 1996
- Alternative Pharmacotherapies for Steroid-Dependent AsthmaChest, 1995
- Alternative Treatments for Asthma: Assessing the NeedJournal of Asthma, 1992
- Glucocorticoid Resistance in Chronic Asthma: Peripheral Blood T Lymphocyte Activation and Comparison of the T Lymphocyte Inhibitory Effects of Glucocorticoids and Cyclosporin AAmerican Review of Respiratory Disease, 1991
- Identification of Activated T Lymphocytes and Eosinophils in Bronchial Biopsies in Stable Atopic AsthmaAmerican Review of Respiratory Disease, 1990
- CD4 T-Lymphocyte Activation in Acute Severe Asthma: Relationship to Disease Severity and Atopic StatusAmerican Review of Respiratory Disease, 1990