Eine alternative Synthese von Homohistamin und strukturverwandten (Imidazol-4-yl)alkylaminen/An Alternative Synthesis of Homohistamine and Structurally Related (Imidazole-4-yl)alkylamines
Open Access
- 1 February 1987
- journal article
- research article
- Published by Walter de Gruyter GmbH in Zeitschrift für Naturforschung B
- Vol. 42 (2) , 238-242
- https://doi.org/10.1515/znb-1987-0220
Abstract
Bromination of N-(4-oxopentyl)phthalimide (3) leads to isomeric bromoketones 2a and 2e, which undergo cyclisation with formamidine in liquid ammonia to yield homohistamine (1a) and 5-methylhistamine (1e). Similarly racemic a-methyl-(1b) and 2-methylhomohistamine (1c) are synthesized. The resolution of 1b is achieved using (+)-and (-)-di-0-(4-toluoyl)tartaric acid. 1 are intermediates in the synthesis of impromidine like, H2 -histaminergic compounds.This publication has 1 reference indexed in Scilit:
- The histamine H2-receptor agonist impromidine: synthesis and structure activity considerationsJournal of Medicinal Chemistry, 1985