Antigen-Antibody Precipitates in Solid Medium with Influenza Virus

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Abstract
Summary: Techniques for studying the diffusion of antigens and antibodies in an agar medium have been applied to several strains of influenza virus. When either rabbit hyper-immune or convalescent ferret sera were mixed with agar, introduced into small tubes and the virus preparations layered upon the solid mixture, bands of precipitate formed in the appropriate tubes. This phenomenon has been shown to be strain-specific and therefore was interpreted as being due to the union of virus antigens and corresponding antibodies. The strain-specific lines of precipitate were also obtained when the virus antigens and antibodies were allowed to diffuse toward each other from depressions in agar contained by Petri dishes.